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Welcome to the Basic Science Network

Join us for the Basic Science Network Keynote Plenary: Nicotine During Adolescence: Mechanisms leading to Long-term changes in cognition
Thursday, February 21, 2019
Time: 8:30 a.m. - 9:30 a.m.Session
Chair:  Marina Picciotto, PhD


Presenter: Huib Mansvelder, PhD, Professor of Neurophysiology, Head of Department, Integrative Neurophysiology, Vrije Universiteit Amsterdam, The Netherlands

Huib Mansvelder received his PhD in Neurophysiology from the Vrije Universiteit Amsterdam in 1999. In his thesis, he investigated the control of large dense-core vesicle release by voltage-gated calcium channels in neuroendocrine cells in the pituitary. During his postdoctoral research with Dan McGehee at the University of Chicago, he studied drug-induced synaptic plasticity in dopamine neurons, and found mechanisms by which nicotinic receptors alter glutamatergic and GABAergic synaptic transmission in the VTA. During his second postdoc at Columbia University New York with Rafael Yuste, rapid calcium dynamics in dendritic spines were studied using 2photon imaging. In the summer of 2002, Huib started his own lab at VU University in Amsterdam. He became full professor in 2008 and heads the department of Integrative Neurophysiology since. His research focuses on how the prefrontal cortex orchestrates attention behaviour in rodents, in particular in interaction with subcortical brain areas, such as the basal forebrain, and how drugs of abuse such as nicotine affect these processes. In addition, his lab investigates how neuronal microcircuits in the human neocortex are organized, both anatomically as well as functionally, and how properties of human neurons relate to human cognition.


About the Basic Science Network

Charge:  To provide an outlet for SRNT members undertaking basic science research to network with one another; to provide guidance to the SRNT Board and committees as necessary to better inform programs and/or discussions that address basic science; to help SRNT advance the field of basic science research globally.

What we define as Basic Science for SRNT: Any field of study where data are collected and/or analyzed with the intent of understanding the etiology, the mechanisms, or the consequences of tobacco/nicotine use. Examples include:

  • Behavioral and pharmacological studies conducted in pre-clinical (any animal model, including humans) and clinical models
  • In vitro experiments on cell lines and immortalized lymphoblastoid cells fMRI studies
  • Genetic, epigenetic, and/or environmental influences on tobacco/nicotine use
  • Effects of flavorants, tobacco derivatives, and/or metabolites on the use of tobacco products
  • Effects of tobacco/nicotine on a variety of factors, including tumor growth, social and/or physical health, and self-concept


  • Brett Froeliger, PhD
  • Jill Turner, PhD
Advisory Committee
  • Rick Bevins, PhD

  • Adriaan Bruijnzeel, PhDM.
  • Imad Damaj, PhD 
  • Thomas Gould, PhD
  • Munir Gunes Kutlu, PhD 
BSN Trainee Task Force
  • Miranda Fisher, PhD
  • Valeria Lallai, PhD
  • Theresa Patten, PhD


 Basic Science Network Publication: Fowler CD, Gipson CD, Kleykamp A, Rupprecht LE, Rees VW, Gould TJ, Oliver J, Bagdas D, Damaj MI, Schmidt HD, Harrell PT, Duncan A, and DeBiasi M, on behalf of the Basic Science Network of the Society for Research on Nicotine and Tobacco (2017) Basic science and public policy: Informed regulation for nicotine and tobacco products. Nicotine and Tobacco Research, Epub ahead of print.

PMID: 29065200 


From Our Field: Scientist Spotlight  

If you would like to nominate a scientist to be interviewed for a future Scientist Spotlight edition, please email Christie Fowler,, and include 'SRNT Basic Science Scientist Spotlight Nomination' in the email subject line. We encourage nominations for individuals at all levels (junior to senior scientists) in Academia or Industry. We look forward to receiving your nominations!


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